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Ecological interactions are rarely taken into account in environmental risk assessment. The objective of this work was to assess how interspecific competition affects the way plant species react to herbicides and more specifically how it modifies the concentration-response curves that can be built using ecotoxicological bioassays. To do this, we relied on the results of ecotoxicological bioassays on six herbaceous species exposed to isoproturon under two conditions: in presence and in absence of a competitor. At the end of the experiments, eleven endpoints were measured. We modelled these data using a hierarchical modelling framework designed to assess the effects of competition on each of the four parameters of the concentration response curves (e.g. the level of response at the control or the concentration at the inflection point of the curve) simultaneously for the six species. The modelled effects could be of three types, 1) competition had no effect on the parameter, 2) competition had the same effect on the parameter for all species and 3) competition had a different effect on the parameter for each species. Our main hypothesis was that different species would react differently to competition. Results showed that about a half of the estimated parameters showed a modification under competition pressure among which only a fourth showed a species-specific effect, the three other fourth showing the same effect between the different species. Our initial hypothesis was thus not supported as species tended to react in the same way to competition. The competition effect on plants was mainly negative, thus showing that they were more affected by isoproturon under competition pressure. This study therefore establishes how competition modifies plant responses to chemical stress and how this interaction varies from one species to the other.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146108 | DOI Listing |
J Biochem Mol Toxicol
January 2025
Department of Pharmaceutical Chemistry, Division of Computer-Aided Drug Design, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
A series of 2,4-disubstituted pyrimidine derivatives bearing 5-substituted-1,3,4 thidiazole were devised and synthesized based on the binding mode of the approved drug Osimertinib with the ATP competitive site of EGFR-L858R/T790M in order to increase selectivity towards double mutant EGFR and potent antitumor activity. Their cellular bioactivity and corresponding enzyme inhibition were studied, and it was revealed that several compounds had significant biological activity and selectivity when compared to the control compounds. One of the most promising compound 8, substantially suppressed the proliferation of H1975 cells and showed significant inhibition of double mutant EGFR-L858R/T790M TK with IC values of 0.
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December 2024
Institute of Chemical Sciences and Technologies "G. Natta", National Research Council of Italy, Via Mario Bianco 9, 20131 Milan, Italy.
Affitins are a class of small artificial proteins, designed as alternatives to antibodies for therapeutic, diagnostic, and biotechnological applications. Recent patents by Bracco Imaging S.p.
View Article and Find Full Text PDFCogn Neurodyn
December 2024
Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Tianjin, China.
EEG decoding plays a crucial role in the development of motor imagery brain-computer interface. Deep learning has great potential to automatically extract EEG features for end-to-end decoding. Currently, the deep learning is faced with the chanllenge of decoding from a large amount of time-variant EEG to retain a stable peroformance with different sessions.
View Article and Find Full Text PDFEcol Evol
December 2024
Univ Lille, CNRS, UMR 8198-Evo-Eco-Paleo Lille France.
The growing urbanization process is accompanied by the emergence of new habitats for wildlife, and cities are sometimes seen as refuges for pollinators such as wild bees compared to intensively cultivated rural habitats. However, the contrasting living conditions that combine high fragmentation, exposure to pollutants, and heat island effects, with low pesticide use and potentially high availability of resources, make it difficult to predict the overall effect of urban living on the health of wild bees. Moreover, if the responses of wild bee populations in terms of species richness and diversity have been the focus of many recent studies, individual responses to urbanization have been more rarely investigated.
View Article and Find Full Text PDFStructure
December 2024
Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:
Major histocompatibility complex class II (MHC-II) presents antigens to T helper cells. The spectrum of presented peptides is regulated by the exchange catalyst human leukocyte antigen DM (HLA-DM), which dissociates peptide-MHC-II complexes in the endosome. How susceptible a peptide is to HLA-DM is mechanistically not understood.
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