A patient with acute inferior infarct is described who showed increased 201Tl uptake in the anterior chest wall following cardioversion which mimicked increased lung uptake of the tracer. The site of accumulation of 201Tl corresponded to that of 99mTc-pyrophosphate (PYP) and the right sided catheterization revealed almost normal hemodynamic data.
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http://dx.doi.org/10.1007/BF00256633 | DOI Listing |
J Med Phys
September 2024
Department of Physics, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Purpose: This study aims to evaluate the performance of dual-energy window (DEW) and triple-energy window (TEW) scatter correction methods in cardiac SPECT imaging with technetium-99m (Tc-99m) and thallium-201 (Tl-201) radioisotopes.
Materials And Methods: The SIMIND Monte Carlo program was used to simulate the imaging system and produce the required projections. Two phantoms, including the simple cardiac phantom and the NCAT phantom, were used to evaluate the scatter correction methods.
J Environ Radioact
February 2024
Aquafin NV, Dijkstraat 8, 2630, Aartselaar, Belgium.
We present a novel methodology to dynamically calculate dose rates to people and wildlife from hospital-released radionuclides reaching the environment through water treatment plants (WTPs), using the biokinetic model D-DAT for aquatic wildlife, applied to F, I, I, Sm, Tc and Tl. We have also developed a method to calculate doses to WTP workers and to farmers from agricultural practices. This proof-of-concept study simulates a generic source term of radionuclide levels in the Belgian Molse Nete River during the year 2018, chosen because the river flow was very low during that year, which constitutes a very conservative, bounding case.
View Article and Find Full Text PDFMolecules
September 2022
Viewpoint Molecular Targeting, Inc., Coralville, IA 52241, USA.
[Pb]VMT01 is a melanocortin 1 receptor (MC1R) targeted theranostic ligand in clinical development for alpha particle therapy for melanoma. Pb has an elementally matched gamma-emitting isotope Pb; thus, [Pb]VMT01 can be used as an imaging surrogate for [Pb]VMT01. [Pb]VMT01 human serum stability studies have demonstrated retention of the Bi daughter within the chelator following beta emission of parent Pb.
View Article and Find Full Text PDFJ Nucl Cardiol
April 2023
Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
Background: We aimed to explore how the severity of myocardial ischemia affects myocardial sigma-1 receptor (Sig-1R) expression using I-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (I-OI5V) imaging.
Methods And Results: The left coronary artery was occluded for 30, 20, and 10 minute, to vary the severity of myocardial ischemia, followed by reperfusion. Dual-tracer autoradiography of the left ventricular short-axis slices was performed 3 and 7 days after reperfusion.
J Cardiovasc Transl Res
February 2023
Section of Cardiovascular Medicine, Department of Medicine, School of Medicine, Yale University, DANA-3, PO Box 208017, New Haven, CT, 06520, USA.
Following myocardial infarction (MI), maladaptive upregulation of matrix metalloproteinase (MMP) alters extracellular matrix leading to cardiac remodeling. Intramyocardial hydrogel delivery provides a vehicle for local delivery of MMP tissue inhibitors (rTIMP-3) for MMP activity modulation. We evaluated swine 10-14 days following MI randomized to intramyocardial delivery of saline, degradable hyaluronic acid (HA) hydrogel, or rTIMP-3 releasing hydrogel with an MMP-targeted radiotracer (Tc-RP805), Tl, and CT.
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