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Immunogenicity and safety of the third booster dose of the inactivated Japanese encephalitis vaccine in Korean children: A prospective multicenter study. | LitMetric

AI Article Synopsis

  • The inactivated Japanese encephalitis (JE) vaccine schedule in Korea includes two doses at 12-24 months and three booster doses at ages 6, 12, and 12 years.
  • A study aimed to examine the safety and immune response of the third booster dose in healthy Korean children aged 11-13 who had previously received four doses of the vaccine.
  • Results showed a significant increase in neutralizing antibody levels after vaccination, with no serious adverse effects reported, indicating that the third booster is both safe and effective.

Article Abstract

The immunization schedule for the inactivated Japanese encephalitis (JE) vaccine in Korea is a two-dose primary series at 12-24 months of age and three booster doses at 12 months after primary schedule and at 6 and 12 years of age. The aim of this study was to investigate immunogenicity and safety of the third booster dose of the inactivated JE vaccine, as well as the long-term immunogenicity of the second booster dose in Korean children. Healthy children aged 11-13 years, primed and given four doses of inactivated JE vaccines were included. All subjects received the third booster dose of the JE vaccine. Neutralizing antibody (NTAb) titers were assessed before and 4-6 weeks after vaccination using plaque reduction neutralization test (PRNT), and were considered to be protective at ≥ 1:10. Local and systemic adverse events were monitored for 4 weeks after vaccination. Before and after booster vaccination, all seroprotection rates were 100%. Geometric mean titer (GMT) showed a 6.05-fold increase, from 139.11 (95% CI: 110.76, 174.71) to 841.53 (95% CI, 714.25, 991.50). The local tolerability and systemic safety profiles were favorable, with no serious adverse events. In conclusion, the third booster dose of the inactivated JE vaccine was demonstrated to be safe and immunogenic in Korean children when administered according to the current immunization schedule.

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Source
http://dx.doi.org/10.1016/j.vaccine.2021.02.076DOI Listing

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