This study reports preparation and physicochemical characterization of natural antimicrobials (Origanum Syriacum essential oil (OSEO), shrimp chitosan nanoparticles (CSNPs)) and new imidazolium ionic liquid-supported Zn(II)Salen. These antimicrobials were separately or co-encapsulated by CSNPs to fabricate novel antimicrobial nanoplatforms "NPFs" (OSEO-loaded CSNPs (NPF-1), Zn(II)Salen-loaded CSNPs (NPF-2), and Zn(II)Salen@OSEO-loaded CSNPs (NPF-3)). The finding of loading, encapsulation, and antimicrobial release studies confirm the suitability of CSNPs for nanoencapsulation of Zn(II)Salen and OSEO. All NPFs can significantly suppress the growth of microbial species with performances dependent upon the microbial strain and nanoplatform concentration. The susceptibility of microbes toward new antimicrobials was as follows; Gram-positive bacteria > Gram-negative bacteria > fungi. The amazing physicochemical features of new nanoplatforms and their bioactive ingredients (Zn(II)Salen, OSEO, and CSNPs) signify the importance of our designs for developing a new generation of nanopharmaceuticals supported both natural products and biogenic ionic metal cofactors, targeting the multidrug resistant (MDR) pathogens.
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http://dx.doi.org/10.1016/j.carbpol.2021.117834 | DOI Listing |
Br Poult Sci
August 2024
Faculty of Arts and Sciences, Biology Department, Holy Spirit University of Kaslik, Jounieh, Lebanon.
1. The extensive use of antimicrobials in poultry production may contribute to the emergence of resistant bacteria. This study was conducted to determine the prevalence and resistance of different strains isolated from raw chicken meat and to investigate the possibility to use Lebanese native oregano essential oils as alternatives.
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May 2024
Department of Chemistry, Faculty of Science, Beirut Arab University, Riad El Solh, P.O. Box 11-5020, Beirut 11072809, Lebanon.
Plants (Basel)
January 2024
Department of Agriculture and Food Engineering, School of Engineering, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon.
Indigenous to Lebanon, L. and D.C.
View Article and Find Full Text PDFMolecules
March 2023
Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, Poland.
Essential oils (EOs) with established and well-known activities against human pathogens might become new therapeutics in multidrug-resistant bacterial infections, including respiratory tract infections. The aim of this study was to evaluate the antimicrobial activity of EOs obtained from several samples of , and cultivated in Poland. EOs were analyzed by GC-MS and tested against four bacterial strains: (MRSA), , and .
View Article and Find Full Text PDFMol Biol Rep
January 2023
Faculty of Science and Arts, Department of Biology, Hitit University, Çorum, Turkey.
Background: The aim of this study is to investigate the antimicrobial activities of the species belonging to the genera Origanum L., Thymus L., and Thymbra L.
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