AI Article Synopsis
- The study investigates how the porosity of alginate hydrogels affects drug release, with two different formulations created using distinct crosslinkers.
- The results revealed that the porous hydrogel (Alg-Nb) allowed for faster drug release due to its adjustable porosity, while the non-porous hydrogel (Alg-FA) released drugs slowly.
- Notably, the porous hydrogels demonstrated the ability to sustainably release the drug doxorubicin over a period of 35 days.
Article Abstract
Task-specific drug release is essential in the development of hydrogels as drug delivery systems. The aim of the study is to report the effect of porosity on alginate hydrogels, which may be controlled by the design of crosslinkers, on drug release behavior. Two alginate-based hydrogels were prepared: alginate-norbornene (Alg-Nb) crosslinked by disulfide-tetrazine (S-Tz; hydrogel A) and alginate-furfuryl amine (Alg-FA) crosslinked by disulfide-maleimide (S-Ma; hydrogel B). Results showed the porosity of hydrogel A was controllable by adjusting the amount of S-Tz. Gel formation was facilitated by a "click" reaction between Alg-Nb and S-Tz, producing nitrogen gas, which, in turn, acted as an in-situ pore generator. Hydrogel B showed a non-porous morphology, as gelation was processed via addition reaction between Alg-FA and S-Ma, which produced no by-product. The study showed that crosslinker proportion and porosity were significant factors influencing drug release behavior of the alginate hydrogels. The presence of a porous structure increased the drug release while non-porous hydrogels led to a very slow release. In addition, the porous alginate hydrogels could sustainably release doxorubicin for 35 days.
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| http://dx.doi.org/10.1016/j.carbpol.2021.117779 | DOI Listing |
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