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Advance Glycation End Products Inhibition by Peel Extract; Characterization, LCMS-QTOF Analysis, and Biological Evaluation.
Food Sci Nutr
December 2024
NPRL, Department of Pharmacognosy, Faculty of Pharmacy Gomal University Dera Ismail Khan Khyber Pakhtunkhwa Pakistan.
Advance glycation end products (AGEs) are the main reason for diabetic complications. Persistent hyperglycemia and non-enzymatic glycation increase the rate of AGEs formation. Natural functional food-based approaches are mainly under investigation these days to discover new treatment options.
View Article and Find Full Text PDFSTING exerts antiviral innate immune response by activating pentose phosphate pathway.
Cell Commun Signal
December 2024
School of Life Sciences, Henan University, Kaifeng, Henan Province, China.
Background: The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.
Methods: Metabolomics analysis was used for detecting metabolic alterations in spleens from STING knockout (KO) and wild-type (WT) mice.
Assessment of mitochondrial function and its prognostic role in sepsis: a literature review.
Intensive Care Med Exp
November 2024
Laboratory of Neurotrauma and Biomarkers, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Sepsis is characterized by a dysregulated and excessive systemic inflammatory response to infection, associated with vascular and metabolic abnormalities that ultimately lead to organ dysfunction. In immune cells, both non-oxidative and oxidative metabolic rates are closely linked to inflammatory responses. Mitochondria play a central role in supporting these cellular processes by utilizing metabolic substrates and synthesizing ATP through oxygen consumption.
View Article and Find Full Text PDFα-Glucosidase isoform G contributes to heme detoxification in and its knockdown affects metacyclogenesis.
Curr Res Insect Sci
October 2024
Laboratório Integrado de Biociências Translacionais (LIBT), NUPEM/UFRJ, Macaé, RJ, Brazil.
Article Synopsis
- * This study explores the role of the enzyme α-glucosidase isoform G (Rp-αGluG) in heme detoxification, revealing that its knockdown leads to reduced hemozoin production and impacts the insect’s overall health, including lower egg production and hatching rates.
- * The findings emphasize the significant role of Rp-αGluG in the insect's digestion, reproduction, and life cycle, offering insights for developing new strategies to disrupt he
Mechanistic Insights on Coverage-Dependent Selectivity Limitations in Vinyl Acetate Synthesis.
ChemSusChem
November 2024
Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
Developing improved catalysts for sustainable chemical processes often involves understanding atomistic origins of catalytic activity, selectivity, and stability. Using density functional theory and steady-state kinetic analyses, we probe the elementary steps that form decomposition products that limit selectivity in vinyl acetate (VA) synthesis on Pd surfaces covered with acetate species. Acetate formation and coupling with ethylene control the VA formation catalytic cycle and steady-state coverage, but acetate and ethylene can separately decompose to form CO.
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