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The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface. | LitMetric

The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface.

Curr Biol

Membrane Traffic and Cell Division Lab, Institut Pasteur, UMR3691, CNRS, 25-28 rue du Dr Roux, 75015 Paris, France. Electronic address:

Published: May 2021

AI Article Synopsis

Article Abstract

The midbody at the center of the intercellular bridge connecting dividing cells recruits the machinery essential for the final steps of cytokinesis. Successive abscission on both sides of the midbody generates a free midbody remnant (MBR) that can be inherited and accumulated in many cancer, immortalized, and stem cells, both in culture and in vivo. Strikingly, this organelle was recently shown to contain information that induces cancer cell proliferation, influences cell polarity, and promotes dorso-ventral axis specification upon interaction with recipient cells. Yet the mechanisms by which the MBR is captured by either a daughter cell or a distant cell are poorly described. Here, we report that BST2/tetherin, a well-established restriction factor that blocks the release of numerous enveloped viruses from the surface of infected cells, plays an analogous role in retaining midbody remnants. We found that BST2 is enriched at the midbody during cytokinesis and localizes at the surface of MBRs in a variety of cells. Knocking out BST2 induces the detachment of MBRs from the cell surface, their accumulation in the extracellular medium, and their transfer to distant cells. Mechanistically, the localization of BST2 at the MBR membrane is both necessary and sufficient for the interaction between MBRs and the cell surface. We thus propose that BST2 tethers post-cytokinetic midbody remnants to the cell surface. This finding reveals new parallels between cytokinesis and viral biology that unexpectedly extend beyond the ESCRT-dependent abscission step.

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Source
http://dx.doi.org/10.1016/j.cub.2021.02.039DOI Listing

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