AI Article Synopsis
- - Platinum(IV) complexes combined with orotic acid show effective targeting of liver cancer cells, particularly in Hep G2 cells, indicating higher activity and uptake.
- - The increased activity is linked to the higher expression of Organic Anion Transporter 2 (OAT2) in Hep G2 cells, suggesting that OAT2 plays a key role in the uptake of these complexes, especially when the OAT2 inhibitor is present.
- - Unlike traditional chemotherapy drugs like cisplatin and oxaliplatin, these platinum(IV) complexes are not hindered by the copper transporter ATP7B, making them more promising for treating liver cancer.
Article Abstract
Platinum(IV) complexes of orotic acid selectively target liver cancer cells displaying enhanced activity and higher uptake in Hep G2. The comparatively higher expression of Organic Anion Transporter 2 (OAT2) in Hep G2 and decrease in toxicity in the presence of OAT2 inhibitor suggest its involvement in the uptake of the complexes. They are resistant to sequestration by the copper transporter ATP7B, unlike cisplatin and oxaliplatin.
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| http://dx.doi.org/10.1021/acs.inorgchem.0c03803 | DOI Listing |
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