AI Article Synopsis
- Implantable biomaterials are surgical devices that significantly enhance the quality of life for many people around the world.
- Advances in materials science have made these devices safer and more effective, but challenges like post-operative infections and immune responses still persist.
- This review aims to explain the biology behind infections and the body's response to implants, while exploring new techniques like local drug delivery and surface modifications to improve the safety and performance of biomaterials.
Article Abstract
Implantable biomaterials are essential surgical devices, extending and improving the quality of life of millions of people globally. Advances in materials science, manufacturing, and in our understanding of the biological response to medical device implantation over several decades have resulted in improved safety and functionality of biomaterials. However, post-operative infection and immune responses remain significant challenges that interfere with biomaterial functionality and host healing processes. The objectives of this review is to provide an overview of the biology of post-operative infection and the physiological response to implanted biomaterials and to discuss emerging strategies utilizing local drug delivery and surface modification to improve the long-term safety and efficacy of biomaterials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238864 | PMC |
| http://dx.doi.org/10.1007/s13346-021-00955-0 | DOI Listing |
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