AI Article Synopsis
- Lung cancer is a major cause of cancer deaths, prompting research for new drug strategies.
- This study focuses on the interaction between Flap endonuclease 1 (FEN1) and Heat Shock Protein 70 (HSP 70) to improve cancer treatments.
- Combining the HSP 70 inhibitor (KNK 437) with 5-Fluorouracil (5-FU) enhances the effectiveness of the treatment, suggesting a new approach for targeting FEN1 in lung cancer.
Article Abstract
Unlabelled: Lung cancer is one of the leading causes of cancer deaths worldwide and existing approaches are not enough to manage, and hence, it is important to concentrate on new drug strategies. This study was aimed to identify the interacting partner of Flap endonuclease 1 (FEN1) and its role in cancer treatment. We identified a new FEN1 interacting partner confirmed it as Heat Shock Protein 70 (HSP 70), and its effect on FEN1 expression, in vitro. Additionally, we found that the 5-Fluorouracil's (5-FU) function was significantly improved when used in combination with HSP 70 inhibitor (KNK 437). The findings are interesting, elucidating the synergistic mechanism between two compounds which helps to develop a novel management strategy for over-expressed FEN1 in the lung.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-020-02598-3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907298 | PMC |
| http://dx.doi.org/10.1007/s13205-020-02598-3 | DOI Listing |
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