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HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis.
Front Biosci (Schol Ed)
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in neuroperotection. Consequently, deepening the understanding the role of HSPs in ischemic stroke (IS) risk is crucial for identifying novel therapeutic targets and advancing neuroprotective strategies.
View Article and Find Full Text PDFNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children.
J Integr Neurosci
December 2024
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06519, USA.
Background: The National Institutes of Health (NIH) Toolbox Cognition Battery is increasingly being used as a standardized test to examine cognitive functioning in multicentric studies. This study examines the associations between the NIH Toolbox Cognition Battery composite scores with neuroimaging metrics using data from the Adolescent Brain Cognitive Development (ABCD) study to elucidate the neurobiological and neuroanatomical correlates of these cognitive scores.
Methods: Neuroimaging data from 5290 children (mean age 9.
Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study.
J Integr Neurosci
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
Background: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date, molecular genetic studies on the involvement of genes encoding proteins of the HSP40 family in IS have not yet been carried out.
Aim: We sought to determine whether nine single nucleotide polymorphisms (SNPs) in genes encoding HSP40 family proteins (, , , , and ) are associated with the risk and clinical features of IS.
Comparison of different group-level templates in gradient-based multimodal connectivity analysis.
Netw Neurosci
December 2024
Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
The study of large-scale brain connectivity is increasingly adopting unsupervised approaches that derive low-dimensional spatial representations from high-dimensional connectomes, referred to as gradient analysis. When translating this approach to study interindividual variations in connectivity, one technical issue pertains to the selection of an appropriate group-level template to which individual gradients are aligned. Here, we compared different group-level template construction strategies using functional and structural connectome data from neurotypical controls and individuals with autism spectrum disorder (ASD) to identify between-group differences.
View Article and Find Full Text PDFLanguage Dominance in Left-Handers: Unveiling Left Hemisphere Global Dominance With Specific Right Hemisphere Regional Dominance.
Cureus
November 2024
Department of Neurosurgery, Fukushima Medical University, Fukushima, JPN.
Introduction The degree to which each human brain hemisphere governs specific cognitive processes, such as language and handedness (the preference or dominance of one hand over the other), varies across individuals. Research has explored the nature of language laterality in left-handed (LH) individuals, indicating that left-hemisphere dominance for language is commonly observed across both left- and right-handed populations. Advanced imaging techniques, including functional transcranial Doppler sonography and fMRI, have revealed subtle differences in language lateralization between LH and right-handed (RH) individuals, particularly in semantic processing tasks.
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