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| http://dx.doi.org/10.52082/jssm.2021.179 | DOI Listing |
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ALS Motor Observational Telemedicine Objective Rasch-Built Assessment: A Quantitative Scale for the Era of Teleneurology.
Neurol Clin Pract
April 2025
Department of Neurology, Emory University School of Medicine, Atlanta, GA.
Background And Objectives: Telemedicine has become a mainstay of ALS clinical care, but there is currently no standardized approach for assessing and tracking changes to the neurologic examination in this format. The goal of this study was to create a standardized telemedicine-based motor examination scale to objectively and reliably track ALS progression and use Rasch methodology to validate the scale and improve its psychometric properties.
Methods: A draft telemedicine examination scale with 25 items assessing movement in the bulbar muscles, neck, trunk, and extremities was created by an ALS expert panel, incorporating input from patient advisors.
Nanoformulation innovations: Revolutionizing precision in migraine therapy.
Iran J Basic Med Sci
January 2025
Departments of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes, and behavioral therapy, many migraine sufferers do not receive adequate relief or experience intolerable side effects. Hence, the present review aims to evaluate the nanoformulation regarding migraine therapy.
View Article and Find Full Text PDFMeasuring implicit associations with behaviours to improve resident mood: development of implicit association tasks for nursing home care providers.
Int J Nurs Stud Adv
June 2025
Department of Primary and Community Care, Radboud University Medical Center, Research Institute for Medical Innovation, Radboudumc Alzheimer Center, Geert Grooteplein 21, 6525 EZ Nijmegen, the Netherlands.
Objective: To develop and evaluate instruments for measuring implicit associations of nursing home care providers with behaviours aimed at improving resident mood.
Method: Study 1 ( = 41) followed an iterative approach to develop two implicit association tasks measuring implicit attitude (positive versus negative valence) and motivation (wanting versus not wanting) regarding mood-improving behaviours, followed by an evaluation of the content validity for target stimuli representing these behaviours. In Study 2 ( = 230), the tasks were assessed for stimulus classification ease (accuracy and speed) and internal consistency.
Increasing robustness of assay for immnosuppressive effect of mesenchymal stromal/stem cells: The role of inflammatory cytokine production by peripheral blood mononuclear cells.
Regen Ther
March 2025
Division of Drugs, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki Ward, Kawasaki City, Kanagawa, 210-9501, Japan.
Introduction: The Quality by Design (QbD) approach for developing cell therapy products using mesenchymal stromal/stem cells (MSCs) is a promising method for designing manufacturing processes to improve the quality of MSC products. It is crucial to ensure the reproducibility and robustness of the test system for evaluating critical quality attributes (CQAs) in the QbD approach for manufacturing of pharmaceutical products. In this study, we explored the key factors involved in establishing a robust evaluation system for the immunosuppressive effect of MSCs, which can be an example of a CQA in developing and manufacturing therapeutic MSCs for treating graft-versus-host disease, , and we have identified method attributes to increase the robustness of a simple assay to assess the immunosuppressive effects of MSCs.
View Article and Find Full Text PDFSCALPDEX Questionnaire: creation and validation of the Polish language version.
Postepy Dermatol Alergol
December 2024
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Introduction: Assessing the quality of life (QoL) in patients with various diseases is essential for understanding their well-being and guiding clinical management. Dermatological conditions, particularly those affecting the scalp, significantly impact QoL due to their visible nature, which can affect appearance and social interactions. While general QoL instruments like the Dermatology Life Quality Index (DLQI) exist, disease-specific tools like SCALPDEX are necessary for capturing the unique challenges faced by patients with scalp disorders.
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