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PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos. | LitMetric
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PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos.

Sophiko Tsikarishvili Margarita Karapetian Nina Kulikova Giorgi Zaalishvili

Biochem Biophys Res Commun

Chromatin Biology Laboratory, Institute of Cellular and Molecular Biology, Agricultural University of Georgia, Kakha Bendukidze Campus, 240 David Aghmashenebeli Alley, 0131, Tbilisi, Georgia. Electronic address:

Published: April 2021

In the present study the role of poly(ADP)ribosylation on rubitecan induced caspase dependent cell death was evaluated. We show that Top1 poisoning by rubitecan induces caspase mediated apoptosis which was reduced by PARP inhibitor olaparib in zebrafish embryo. Collectively our data introduces zebrafish as a valuable model for PARP related biomedical research.

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http://dx.doi.org/10.1016/j.bbrc.2021.03.005DOI Listing

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