AI Article Synopsis
- * Factors like sleep fragmentation and oxygen levels change the microbiome, while changes in microbiota can impact sleep patterns.
- * Emerging research indicates that adjusting the microbiome using probiotics or other methods might help treat OSA and its related health issues like hypertension and obesity.
Article Abstract
Recent evidence has highlighted important associations between obstructive sleep apnea and the microbiome. Although the intricacies of the pathophysiologic mechanisms are not well understood, available evidence suggests a bidirectional relationship between obstructive sleep apnea and microbiota composition. Sleep fragmentation, intermittent hypoxia, and intermittent hypercapnia all play significant roles in altering the microbiome, and initial evidence has shown that alterations of the microbiota affect sleep patterns. Animal model evidence strongly supports the idea that the microbiome mediates disease states associated with obstructive sleep apnea including hypertension, atherosclerosis, and obesity. While evidence is limited, several studies suggest there may be a role for treatment of obstructive sleep apnea and obstructive sleep apnea-related comorbidities through alteration of the microbiome with probiotics, prebiotics, and microbiota transplantation.
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| http://dx.doi.org/10.1093/sleep/zsab061 | DOI Listing |
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