Two polycyclic thioalkaloides dassonmycins A () and B () were isolated from SCSIO 40065 associated with marine sponge sp. Structures of and were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction experiments, to have a 6/6/6/6-fused tetracyclic ring featuring a naphthoquinone[2,3-]piperazine[1,2-]thiomorpholine scaffold. Compound formed a caged core through an additional ether bridge. Both compounds exhibited moderate antibacterial and cytotoxic activities.
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Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived SCSIO 40065.
Org Lett
April 2021
Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Two polycyclic thioalkaloides dassonmycins A () and B () were isolated from SCSIO 40065 associated with marine sponge sp. Structures of and were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction experiments, to have a 6/6/6/6-fused tetracyclic ring featuring a naphthoquinone[2,3-]piperazine[1,2-]thiomorpholine scaffold. Compound formed a caged core through an additional ether bridge.
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