Fine structure of distribution of electric potential difference (EPD) in human skin of some points on arms, body and face relative to a referent point on the neck was investigated. Diurnal variations of EPD fine structure for individuals and seasonal differences expressed in an increase of the amplitude of variations and shift of EPD mean values to the positive region in winter as compared with summer were observed. The indicated peculiarities are connected with external factors and reflect changes of metabolic activity of organism living activity processes.

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