AI Article Synopsis
- The study presents a method for creating tetrasubstituted benzoin derivatives using palladium-catalyzed decarboxylative allylic alkylation of specific enol carbonates.
- It highlights the necessity of preparing the starting material as a single enolate isomer to achieve the best enantioselectivity in the reaction.
- The products formed have multiple reactive sites, offering opportunities for further synthesis of complex stereochemically rich compounds.
Article Abstract
The enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted α-hydroxy acyclic enol carbonates providing tetrasubstituted benzoin derivatives is reported. Investigation into the transformation revealed that preparation of the starting material as a single enolate isomer is crucial for optimal enantioselectivity. The obtained alkylation products contain multiple reactive sites that can be utilized toward the synthesis of stereochemically rich derivatives. COMMUNICATION.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942817 | PMC |
| http://dx.doi.org/10.1002/adsc.201901281 | DOI Listing |
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