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Gene Expression Profiling of Monozygotic Twins Affected by Psoriatic Arthritis. | LitMetric

Gene Expression Profiling of Monozygotic Twins Affected by Psoriatic Arthritis.

Open Access Rheumatol

Rheumatology Unit, Department of Medical Sciences and Public Health, University of Cagliari, University Clinic AOU, Cagliari, 09042, Italy.

Published: March 2021

AI Article Synopsis

  • Psoriatic Arthritis (PsA) is influenced by a mix of genetic, environmental, and epigenetic factors, and there's a need for biomarkers to improve diagnosis and track disease progression.
  • This study examines the gene expression differences in monozygotic twins with varying severity of PsA, using advanced profiling techniques to uncover transcriptomic and epigenomic insights.
  • Results indicated that the twin with more severe symptoms had increased expression of genes related to immune processes, highlighting the potential of twin studies to assess the contributions of genetics and other factors in complex diseases like PsA.

Article Abstract

Introduction: Psoriatic Arthritis (PsA) is a multifactorial disease, where the relative burden of genetic, epigenetic and environmental factors in clinical course and damage accrual is not yet definitively clarified. In clinical practice, there is a real need for useful candidate biomarkers in PsA diagnosis and disease progression, by exploring its underlying transcriptomic and epigenomic mechanisms. This work aims to profile the transcriptome in monozygotic (MZ) twins with psoriatic arthritis (PsA) highly concordant for clinical presentation, but discordant for the radiographic outcomes' severity.

Methods: We describe i) the clinical case of two MZ twins; ii) their comparative gene expression profiling (HTA 2.0 Affymetrix) and iii) signal pathways and pathophysiological processes in which differentially expressed genes are involved (in silico analysis by the IPA software, QIAGEN).

Results: One hundred sixty-three transcripts and 36 coding genes (28 up and 8 down) were differentially expressed between twins, and in the brother with the most erosive form, the transcriptomic profiling highlights the overexpression of genes known to be involved in immunomodulatory processes and on a broad spectrum of PsA manifestations.

Discussion: Twins' clinical cases are still a gold mine in medical research: twin brothers are ideal experimental models in estimating the relative importance of genetic versus nongenetic components as determinants of complex phenotypes, non-Mendelian and multifactorial diseases as PsA.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939499PMC
http://dx.doi.org/10.2147/OARRR.S291391DOI Listing

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