A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d0cc08146a | DOI Listing |
Publication Analysis
Top Keywords
minimal motif
8
left-handed g-quadruplex
8
lhg4 formation
8
lhg4
5
novel minimal
4
motif
4
motif left-handed
4
g-quadruplex formation
4
formation study
4
study left-handed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!