Fetal compressive intrapericardial teratoma is a rare and life-threatening condition, qualifying as a high-acuity low-occurrence (HALO) event. To prepare for delivery and immediate neonatal management, specialists from pediatric cardiology, cardiac surgery, maternal-fetal-medicine, neonatology, cardiac anesthesia, critical care, clinical perfusion, obstetrical nursing, and operating room nursing convened. An in situ operating room simulation was used to identify and introduce key team members, derive and practice the anticipated clinical management algorithm, position human and equipment resources strategically, and ensure that each specialist team was familiar with the environment and available equipment. As rehearsed in the simulation, the cesarean delivery of the patient and neonatal cardiac surgery was uncomplicated and yielded a favourable clinical outcome. A patient-specific HALO simulation preparation (PSHSP) can facilitate positive clinical outcomes and improve health care team confidence in HALO scenarios such as the birth of newborns anticipated to have cardiorespiratory instabilty.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.cjca.2021.02.021 | DOI Listing |
Pharmacoeconomics
January 2025
Division of Pulmonology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Shengli Road, Tainan, 704, Taiwan.
Background And Objective: Approximately half of lung adenocarcinomas in East Asia harbor epidermal growth factor receptor (EGFR) mutations. EGFR testing followed by tissue-based next-generation sequencing (NGS), upfront tissue-based NGS, and complementary NGS approaches have emerged on the front line to guide personalized therapy. We study the cost effectiveness of exclusionary EGFR testing for Taiwanese patients newly diagnosed with advanced lung adenocarcinoma.
View Article and Find Full Text PDFAppl Biochem Biotechnol
January 2025
Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq.
The synthesis and characterization of benzo[d]thiazol-2-amine derivatives, which were prepared by reacting benzothiazole with para-aminobenzophenone in ethanol, supplemented with glacial acetic acid. Subsequently, compound (2) was synthesized from compound (1) using NaNO, HPO, and HNO in a water-based solvent, resulting in 2-hydroxy-1-naphthaldehyde. Another derivative, compound (3), was synthesized by reacting compound (1) with vanillin under similar conditions.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Background: Receptor Tyrosine kinase-mediated signaling is indispensable for the cell's normal functioning, the perturbation of which leads to disease conditions. The altered expression and activity of several Receptor Tyrosine kinases (RTKs) are known to regulate the pathophysiology of Alzheimer's disease (AD). However, the mechanistic details remain illusive.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Background: The apolipoprotein ε4 (ApoE4) allele is a major risk factor for sporadic Alzheimer's disease (AD) and was shown to promote amyloid-β (Aβ) accumulation and mediate pathophysiological processes in AD. Although the molecular interaction between Aβ and ApoE is acknowledged, the precise nature of this interaction remains unclear. This study aims to explore the biophysical and biochemical nature of the interaction between Aβ and ApoE in the ε3 and ε4 isoforms.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stanford University, Palo Alto, CA, USA.
Background: Genome-wide association studies (GWAS) have identified thousands of genomic regions associated with complex diseases but understanding the underlying causal mechanisms remains a significant challenge. The FunGen-xQTL project has addressed this by generating and harmonizing molecular quantitative trait loci (xQTL) across multiple layers of molecular traits in human brains, cerebrospinal fluid, and blood-derived cells relevant to neurodegenerative disorders. Existing approaches for integrating xQTL data with GWAS have typically focused on individual molecular traits in individual QTL layers.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!