AI Article Synopsis
- The study focused on creating and optimizing a Curcumin-loaded solid lipid nanoparticles (C-SLNs) patch for effective transdermal delivery using a modified injection method.
- C-SLNs showed a particle size of 170 nm with a high encapsulation efficiency of 90%, and the patch provided a sustained release of the drug for up to 72 hours.
- Adding a permeation enhancer significantly improved skin absorption, making the modified injection method a simple and cost-effective way to develop the patch.
Article Abstract
This study aimed to develop and optimise a Curcumin-loaded SLNs (C-SLNs) patch through a new approach for transdermal delivery. C-SLNs were optimised through the response surface central composite design using the modified injection method. Optimised C-SLNs were loaded into a polyvinyl alcohol-based patch through the backing membrane method. Compatibility studies (FTIR, XRPD) release, skin permeation, accelerated stability, and evaluation studies of the patch were also performed. Prepared C-SLNs exhibited average particle diameter of 170± 2 nm with an encapsulation efficiency of 90 ± 3.5% (w/w) while SEM illustrated spherical shape of particles. release data ensured a sustained release for up to 72 hours. The enhancement ratio of C-SLNs based patch with permeation enhancer (PE) was high up to 6.5 folds as compared to patch without PE. It is concluded that the modified injection method is simple, economical, and less time consuming for the development of C-SLNs patch for the transdermal route.
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| http://dx.doi.org/10.1080/02652048.2021.1899321 | DOI Listing |
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