A comparative study of antianginal propranolol efficacy in an acute test and 7 days after regular therapy in patients with a stable form of angina of effort has shown that the duration of beta-blockade and antianginal action of the drug increases during course therapy at individual doses in a 3-4-fold regimen of administration. Sharp reduction of a degree of the antianginal effect of propranolol was noted almost in 42% of the patients on regular therapy which could be accounted for by an increase in beta-blocker negative inotropic action. In the group of patients in whom propranolol antianginal efficacy was on a decrease during course therapy, not a single clinical or hemodynamic sign was defined permitting the prediction of a reduced effect of propranolol during course therapy.
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