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Molecular Characterization and Pathogenicity Analysis of Porcine Rotavirus A.
Viruses
November 2024
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Porcine rotavirus A (RVA) is one of the major etiological agents of diarrhea in piglets and constitutes a significant threat to the swine industry. A molecular epidemiological investigation was conducted on 2422 diarrhea samples from Chinese pig farms to enhance our understanding of the molecular epidemiology and evolutionary diversity of RVA. The findings revealed an average RVA positivity rate of 42% (943/2422), and the study included data from 26 provinces, primarily in the eastern, southern and southwestern regions.
View Article and Find Full Text PDFTargeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice.
Nutrients
December 2024
Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Background/objectives: The extracellular calcium-sensing receptor (CaSR) is a multifunctional receptor proposed as a possible drug target for inflammatory bowel disease. We showed previously that CaSR inhibition with NPS 2143, a negative allosteric modulator of the CaSR, somewhat ameliorated the symptoms of chemically induced severe colitis in mice. However, it was unclear whether the potential of CaSR inhibition to reduce colitis may have been overshadowed by the severity of the induced inflammation in our previous study.
View Article and Find Full Text PDFEffect of Spirulina on the Rumen Microbiota and Serum Biochemical Parameters of Lambs.
Microorganisms
December 2024
Key Laboratory of Forage Cultivation, Processing and Highly Efficient Utilization of Ministry of Agriculture and Rural Affairs, College of Grassland Science, Inner Mongolia Agricultural University, Hohhot 010019, China.
Spirulina () is rich in a variety of fermentable fibers and prebiotics, which can promote the proliferation of beneficial flora in the intestinal tract of ruminants and optimize the balance of microorganisms in the rumen. The aim of this study was to evaluate whether dietary supplementation with Spirulina has a beneficial effect on the rumen microbial community and serum indices in lambs. For this purpose, 36 lambs with a mean weight of 21.
View Article and Find Full Text PDFThe Effect of Milk-Derived Extracellular Vesicles on Intestinal Epithelial Cell Proliferation.
Int J Mol Sci
December 2024
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem 9166100, Israel.
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammation disorder of the gastrointestinal tract characterized by disrupted intestinal epithelial barrier function. Despite advances in treatment, including biological agents, achieving sustained remission remains challenging for many patients with IBD. This highlights the urgent need for novel therapeutic strategies.
View Article and Find Full Text PDFAdministration of Spermidine and Eugenol Demonstrates Anti-Tumorigenic Efficacy on Metastatic SW620 and Primary Caco-2 Colorectal Cancer Spheroids.
Int J Mol Sci
December 2024
Department of Agricultural and Food Sciences, Alma Mater Studiorum-University of Bologna, 40127 Bologna, Italy.
The anti-cancer potential of eugenol (EUG) is well recognized, whereas that of spermidine (SPD) is subject to dispute and requires further research. The anti-tumorigenic potential of wheat germ SPD (150 µM) and clove EUG (100 µM), alone, in combination as SPD+EUG (50 µM + 100 µM) and, as a supplement (SUPPL; 0.6 µM SPD + 50 µM EUG), was investigated on both metastatic SW620 and primary Caco-2 colorectal cancer (CRC) spheroids.
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