Introduction: Work accidents involving biological material are characterized as those whose exposure involves direct or indirect contact with human or animal blood and biological fluids, with a potential degree of contamination.
Objectives: To investigate the sociodemographic and occupational profile of workers, as well as data on occupational accidents with exposure to biological material in the municipalities that make up the Centro de Referência em Saúde do Trabalhador da Região dos Vales do estado do Rio Grande do Sul (Cerest-Vales/RS).
Methods: Documentary, retrospective, descriptive, quantitative research, where 1,260 Sistema de Informação de Agravos de Notificação (Sinan) notifications were analyzed, between 2014 and 2018. Data were collected in a unit specialized in worker health care.
Results: The sex most affected by accidents was female, with 80.2% of cases, age group of 28 to 33 years (26.4%), and level of education represented mostly by complete high school (55.4%). Health professionals concentrated 84.1% of accidents, most of which occurred with nursing technicians, followed by nurses and doctors. Professionals from different occupations, such as veterinarians, students, janitors and garbage collectors were also exposed. Blood was the organic material that prevailed (81.1%) between accidents and exposure, percutaneous (70.3%). Clinical data revealed the prevalence of patients vaccinated for hepatitis B (90.6%), but 62.7% with (hepatitis B surface antigen, HBsAg) negative; 49.5% of the injured were discharged with a negative source patient and 66% the Comunicação de Acidente de Trabalho (CAT) issued.
Conclusions: Accidents occurred more frequently among females, individuals with low education and health professionals. The weakness in the reports of accidents with professionals with no presumed risk is reiterated, which generates underreporting rates.
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http://dx.doi.org/10.47626/1679-4435-2020-534 | DOI Listing |
Gastric Cancer
January 2025
Department of Medical Oncology, Hospital Clinico Universitario, INCLIVA, Biomedical Research Institute, University of Valencia, Avenida Menendez Pelayo nro 4 accesorio, Valencia, Spain.
Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.
Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.
Adv Sci (Weinh)
January 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Ocular surface chemical injuries often result in permanent visual impairment and necessitate complex, long-term treatments. Immediate and extensive irrigation serves as the first-line intervention, followed by various therapeutic protocols applied throughout different stages of the condition. To optimize outcomes, conventional regimens increasingly incorporate biological agents and surgical techniques.
View Article and Find Full Text PDFSci Rep
January 2025
College of Plant Protection, Biocontrol Engineering Laboratory of Crop Diseases and Pests of Gansu Province, Gansu Agricultural University, Lanzhou, 730070, China.
Recently, a new bacterial disease was detected on cucumber stalks. In order to study the pathogenesis of this disease, the pathogenic bacteria were isolated and identified on the basis of morphological and molecular characteristics, and further analyzed for pathogenicity and antagonistic evaluation. Pathogenicity analysis showed that HlJ-3 caused melting decay and cracking in cucumber stems, and the strain reisolated from re-infected cucumber stalks was morphologically identical to HlJ-3 colonies, which is consistent with the Koch's postulates.
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January 2025
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
Background: Sarcoglycanopathies (SGPs) are limb-girdle muscular dystrophies (LGMDs) that can be classified into four types, LGMDR3, LGMDR4, LGMDR5, and LGMDR6, caused by mutations in the genes, SGCA, SGCB, SGCG, and SGCD, respectively. SGPs are relatively rare in Japan. This study aims to profile the genetic variants that cause SGPs in Japanese patients.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Nuclear speckles are membraneless organelles that associate with active transcription sites and participate in post-transcriptional mRNA processing. During the cell cycle, nuclear speckles dissolve following phosphorylation of their protein components. Here, we identify the PP1 family as the phosphatases that counteract kinase-mediated dissolution.
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