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Vascular endothelial growth factors and angiopoietins as new players in mastocytosis. | LitMetric

AI Article Synopsis

  • - Mastocytosis is a condition where there’s an abnormal increase of mast cells in different organs, often linked to a mutation in the KIT receptor, affecting over 90% of patients.
  • - The study measured levels of various angiogenic factors (like VEGF-A, ANGPT1, ANGPT2) in 64 mastocytosis patients and 64 healthy controls, finding significantly higher concentrations in patients, especially correlating with symptom severity.
  • - Results also indicated that while specific factors (VEGF-A, ANGPT2, VEGF-C) are related to the clinical severity, other factors like ANGPT1 were consistently elevated in all patients compared to controls.

Article Abstract

Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutation in codon 816 of the KIT receptor on mast cells (MCs). The symptoms of mastocytosis patients are related to the MC-derived mediators that exert local and distant effects. MCs produce angiogenic and lymphangiogenic factors, including vascular endothelial growth factors (VEGFs) and angiopoietins (ANGPTs). Serum concentrations of VEGF-A, VEGF-C, VEGF-D, ANGPT1 and ANGPT2 were determined in 64 mastocytosis patients and 64 healthy controls. Intracellular concentrations and spontaneous release of these mediators were evaluated in the mast cell lines ROSA and ROSA and in human lung mast cells (HLMCs). VEGF-A, ANGPT1, ANGPT2 and VEGF-C concentrations were higher in mastocytosis patients compared to controls. The VEGF-A, ANGPT2 and VEGF-C concentrations were correlated with the symptom severity. ANGPT1 concentrations were increased in all patients compared to controls. ANGPT2 levels were correlated with severity of clinical variants and with tryptase levels. VEGF-A, ANGPT1 and VEGF-C did not differ between indolent and advanced mastocytosis. ROSA, ROSA and HLMCs contained and spontaneously released VEGFs and ANGPTs. Serum concentrations of VEGFs and ANGPTs are altered in mastocytosis patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266723PMC
http://dx.doi.org/10.1007/s10238-021-00693-0DOI Listing

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