AI Article Synopsis
- The review focuses on neurogenic orthostatic hypotension (nOH) and neurogenic supine hypertension (nSH), two conditions that affect blood pressure regulation and can cause various symptoms like dizziness and fainting when changing positions.
- nOH leads to low blood pressure when standing, while nSH is high blood pressure when lying down, which can pose risks to cardiovascular health even if symptoms aren't present.
- Treatment is complex because medications that help nOH can worsen nSH, necessitating a tailored management plan that includes both non-drug strategies and medications to address these opposing conditions.
Article Abstract
Purpose Of Review: In autonomic failure, neurogenic orthostatic hypotension (nOH) and neurogenic supine hypertension (nSH) are interrelated conditions characterized by postural blood pressure (BP) dysregulation. nOH results in a sustained BP drop upon standing, which can lead to symptoms that include lightheadedness, orthostatic dizziness, presyncope, and syncope. nSH is characterized by elevated BP when supine and, although often asymptomatic, may increase long-term cardiovascular and cerebrovascular risk. This article reviews the pathophysiology and clinical characteristics of nOH and nSH, and describes the management of patients with both nOH and nSH.
Recent Findings: Pressor medications required to treat the symptoms of nOH also increase the risk of nSH. Because nOH and nSH are hemodynamically opposed, therapies to treat one condition may exacerbate the other. The management of patients with nOH who also have nSH can be challenging and requires an individualized approach to balance the short- and long-term risks associated with these conditions. Approaches to manage neurogenic BP dysregulation include nonpharmacologic approaches and pharmacologic treatments. A stepwise treatment approach is presented to help guide neurologists in managing patients with both nOH and nSH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943503 | PMC |
| http://dx.doi.org/10.1007/s11910-021-01104-3 | DOI Listing |
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Article Synopsis
- The review focuses on neurogenic orthostatic hypotension (nOH) and neurogenic supine hypertension (nSH), two conditions that affect blood pressure regulation and can cause various symptoms like dizziness and fainting when changing positions.
- nOH leads to low blood pressure when standing, while nSH is high blood pressure when lying down, which can pose risks to cardiovascular health even if symptoms aren't present.
- Treatment is complex because medications that help nOH can worsen nSH, necessitating a tailored management plan that includes both non-drug strategies and medications to address these opposing conditions.
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