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Whole-Genome Analysis of Multidrug-Resistant Klebsiella pneumoniae Kp04 Reveals Distinctive Antimicrobial and Arsenic-Resistance Genomic Features: A Case Study from Bangladesh.
Curr Microbiol
November 2024
Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh.
Article Synopsis
- Multidrug-resistant bacteria, especially ESBL-producing strains like Klebsiella pneumoniae, are a major global health threat, with this study focusing on Kp04, a clinical isolate from Bangladesh.
- The investigation revealed high antibiotic resistance, with five isolated K. pneumoniae strains being resistant to 14 out of 21 tested antibiotics while only being sensitive to three specific ones.
- Whole-genome sequencing of Kp04 identified 75 genes associated with ESBL, virulence, and multiple drug resistance, highlighting similarities in virulence and resistance among isolates from Dhaka and Chattogram, indicating possible transmission of these strains in the region.
Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol-Associated Liver Disease.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol-associated liver disease (ALD). Probiotic-postbiotic intervention strategies can effectively relieve ALD by maintaining gut homeostasis. Herein, the efficacy of heat-killed Lactobacillus johnsonii (HKLJ) in mitigating alcoholic liver damage is demonstrated in mouse models of ALD.
View Article and Find Full Text PDFCorrigendum: Development and validation of next-generation sequencing panel for personalized eradication treatment targeting multiple species.
Front Cell Infect Microbiol
October 2024
Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, Republic of Korea.
[This corrects the article DOI: 10.3389/fcimb.2024.
View Article and Find Full Text PDFinfection and inflammatory bowel disease: a 2-sample Mendelian randomization study.
Front Microbiol
October 2024
Department of Digestive Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Introduction: Observational studies have discovered a contradictory phenomenon between infection and inflammatory bowel disease (IBD). The study aimed to confirm the causal association between and IBD, including ulcerative colitis (UC) and Crohn's disease (CD).
Methods: We conducted a Mendelian randomization (MR) study with two sample Genome-Wide Association Studies (GWAS) to determine whether there is a causal relationship between infection and IBD, as well as the possible pathogenic factors that may be involved.
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