AI Article Synopsis
- Pneumocystis jirovecii is a fungal agent that causes pneumonia in humans and is closely related to Pneumocystis found in macaques; however, little is understood about its counterparts in other mammals that don’t infect humans.
- Researchers have sequenced the genomes of various Pneumocystis species from animals like macaques, rabbits, dogs, and rats to better understand their evolutionary adaptations and compare them to those infecting humans.
- This genomic analysis helps reveal important genetic traits related to host adaptation and provides insight into the evolutionary history of P. jirovecii, the only Pneumocystis species that can infect humans.
Article Abstract
Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940399 | PMC |
| http://dx.doi.org/10.1038/s42003-021-01799-7 | DOI Listing |
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