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The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke. | LitMetric

AI Article Synopsis

  • Galectin-3 is an inflammatory mediator linked to stroke progression, and a study of 288 patients with acute ischemic stroke found a strong correlation between higher galectin-3 serum levels and more severe clinical presentations at admission.
  • Statistical analysis showed that patients in the highest quartile of galectin-3 had a significantly worse functional outcome at discharge, with an odds ratio of 3.15, indicating more than triple the risk of poor recovery compared to lower quartiles.
  • The study highlighted that higher galectin-3 levels not only correlate with stroke severity but also serve as a potential prognostic marker for outcomes in ischemic stroke patients.

Article Abstract

Galectin-3, a microglia/macrophage-derived inflammatory mediator, plays a role in the stroke progression. In this single-center prospective study, we included 288 consecutive patients with a first-ever acute ischemic stroke to assess the association between galectin-3 serum level and clinical severity at admission and outcome at discharge by univariate and multivariate logistic regression. The results were presented as odds ratios (OR) and 95% confidence intervals (CI). Patients with high severity and poor outcomes had higher serum levels of galectin-3 (P<0.001 and P<0.001). Multivariate analysis suggested that a galectin-3 serum level in the highest quartile (The lowest three quartiles[Q1-3] as the reference) was associated with poor functional outcome (OR, 3.15; 95% CI, 2.44-3.87). The AUC (standard error) for the NIHSS and the combined model were 0.764 (0.031) and 0.823 (0.027), corresponding to a difference of 0.059 (0.004). This study shows that higher serum levels of galectin-3 are associated with stroke severity at admission and stroke prognosis at discharge in ischemic stroke.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993705PMC
http://dx.doi.org/10.18632/aging.202610DOI Listing

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