AI Article Synopsis
- Moxidectin (MXD) is an antiparasitic drug used for both companion and farm animals, and this study focused on determining its withdrawal period in swine after administration.
- The study utilized a modified HPLC-FLD procedure to measure MXD concentrations in swine edible tissues, achieving good validation metrics with LOD and LOQ values of 0.5 μg/kg and 1 μg/kg respectively.
- Results indicated that fat tissues accumulated the highest levels of MXD, leading to a determined withdrawal period of 26 days for the maximum residue limit (MRL) of 500 μg/kg in fat, contributing to food safety knowledge and medication guidelines.
Article Abstract
Moxidectin (MXD), an antiparasitic drug, is effective for a variety of external and internal parasites in companion and farm animals. This study aimed to calculate the withdrawal period by investigating the residue depletion of MXD in swine edible tissues after pouring at the dosage of 2.5 mg/kg B.W. The concentrations of MXD in swine edible tissues were determined by a modified preparation procedure based on HPLC-FLD. The method was validated giving LOD and LOQ of 0.5 μg/kg and 1 μg/kg respectively with measured recoveries ranging from 62.9%-89.2% at three different concentrations and a precision (RSD) of less or equal to 15.7%. The muscle, liver, kidney and fat tissues were collected at 0.5, 5, 10, 20, 25 d after administration. The results showed that fat was the target tissue with the highest concentration for MXD. The withdrawal period was 26 days for the MRL of 500 μg/kg in fat. The results provide fundamental information to ensure food safety and establishment of a rational medication regimen.
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| http://dx.doi.org/10.1080/19440049.2021.1877833 | DOI Listing |
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