Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/1873-3468.14056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: The goal of this study was to examine the effects of spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss of sensory feedback and alterations in gait biomechanics, including co-contractions of antagonist muscles about the knee and ankle, and reduced pelvic obliquity range-of-motion and pelvic drop. SCS can restore sensation in the missing limb, but its effects on muscle activation and gait biomechanics have not been studied in people with lower-limb amputation.
View Article and Find Full Text PDFDecreases in K63 Polyubiquitination in the Hippocampus Promote the Formation of Contextual Fear Memories in Both Males and Females.
Hippocampus
January 2025
School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Over 90% of protein degradation in eukaryotic cells occurs through the ubiquitin-proteasome system (UPS). In this system, the ubiquitin protein can bind to a substrate on its own or it can form a chain with multiple ubiquitin molecules in a process called polyubiquitination. There are 8 different sites on ubiquitin at which polyubiquitin chains can be formed, the second most abundant of which, lysine-63 (K63), is independent of the degradation process, though this mark has rarely been studied in the brain or during learning-dependent synaptic plasticity.
View Article and Find Full Text PDFTumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations.
ACS Pharmacol Transl Sci
November 2024
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.
The goal of this project was to demonstrate that subpopulations of cells in tumors can uniquely fluctuate in size in response to environmental conditions created during drug treatment, thereby acting as a dynamic "rheostat" to create a favorable tumor environment for growth. The cancer modeling used for these studies was subpopulations of melanoma cells existing in cultured and tumor systems that differed in aldehyde dehydrogenase (ALDH) activity. However, similar observations were found in other cancer types in addition to melanoma, making them applicable broadly across cancer.
View Article and Find Full Text PDFPreparation and Rationale for a Patient-Centered Clinical Outcome Assessment Set of Fluid Overload for Drug Development in Nephrotic Syndrome.
Glomerular Dis
August 2024
Department of Medical Social Sciences, Northwestern University, Chicago, IL, USA.
Introduction: Fluid overload is a source of substantial morbidity for adults and children with nephrotic syndrome (NS). Preparation and Rationale for a Fluid Overload in Nephrotic Syndrome Clinical Outcomes Assessment Set for Drug Development (Prepare-NS, 5UG3FD007308) was funded by the US Food and Drug Administration to develop a core set of patient-reported and observer-reported (for young children) outcome measures of fluid overload for use in pharmaceutical trials across the lifespan.
Methods: The Prepare-NS study team developed the proposed context of use with input from stakeholders.
The energy crisis differentially impacted Swiss and German citizens' energy literacy and efficiency preferences but not their support for climate policies.
Commun Earth Environ
September 2024
Faculty of Psychology, University of Basel, Basel, Switzerland.
The energy crisis reshaped energy politics, resulted in energy price surges, increased energy capacity, and large-scale energy-saving campaigns. While an energy demand reduction was observed in Europe, little is known about how the crisis impacted citizens' climate-relevant judgment and decisions. Here we report a preregistered two-wave cross-national study ( = 1040) spanning the winter of 2022/2023 to investigate how support for renewable energy policies, energy literacy, and energy-efficient product choices developed as this crisis unfolded.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!