AI Article Synopsis
- Invertebrates have become valuable models for studying complex interactions between hosts and microbes, particularly for understanding pathogenic fungi.
- The larvae of certain invertebrates provide a reliable system to analyze the disease-causing abilities and factors of various fungal strains.
- The review discusses different methods for assessing fungal pathogenicity, summarizes mutants tested for virulence, and suggests that while invertebrate models are useful, mammalian models may still be needed for validation.
Article Abstract
The invertebrate has increasingly and widely been used in the last few years to study complex host-microbe interactions. is one of the most pathogenic fungi causing life-threatening diseases in humans and animals. larvae has been proven as a reliable model for the analysis of pathogenesis and virulence factors, enable to screen a large number of strains. This review describes the different uses of to study and provides a comparison of the different protocols to trace fungal pathogenicity. The review also includes a summary of the diverse mutants tested in , and their respective contribution to virulence. Previous investigations indicated that should be considered as an interesting tool even though a mammalian model may be required to complete and verify initial data.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946008 | PMC |
| http://dx.doi.org/10.1080/21505594.2021.1893945 | DOI Listing |
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