AI Article Synopsis
- The albumin-globulin ratio (AGR) has been shown to potentially predict mortality in patients with multiple myeloma, based on a study of 200 patients from 2010 to 2018.
- The study found that a high AGR (above 1.16) is linked to better overall survival (OS) and progression-free survival (PFS), with low AGR indicating worse outcomes.
- Overall, AGR could serve as a useful biomarker for assessing prognosis in multiple myeloma patients, highlighting its importance in clinical settings.
Article Abstract
Objective: The albumin-globulin ratio (AGR) has been identified as a promising prognostic predictor of mortality in patients with hematological malignancies. This study investigated the prognostic significance of AGR in patients with multiple myeloma.
Methods: Two hundred patients diagnosed with multiple myeloma from January 2010 to October 2018 were retrospectively analyzed and followed up until December 2019. Kaplan-Meier curves and multivariate Cox regression analysis were applied to detect the prognostic value of AGR.
Results: The median follow-up period was 36 months. The optimal cutoff of AGR was 1.16 according to receiver operating characteristic curve analysis. High AGR was significantly correlated with better overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that low AGR was an independent prognostic factor for worse OS (hazard ratio [HR] = 1.82, 95% confidence interval [CI] = 1.15-2.94) and PFS (HR = 1.53, 95% CI = 1.09-2.17).
Conclusions: AGR may represent a potential prognostic biomarker in patients with multiple myeloma. We demonstrated that high AGR was associated with a favorable overall survival and progression-free survival in patients with multiple myeloma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944530 | PMC |
| http://dx.doi.org/10.1177/0300060521997736 | DOI Listing |
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