AI Article Synopsis
- Failure to assess the toxicities of new drug candidates is primarily linked to inadequate pharmacokinetic evaluations, highlighting the need for improved methodologies.
- Various innovative techniques, such as 3D cell cultures and bio microfluidic models, are being developed to enhance drug metabolism profiling, though further research on their automation and efficiency is necessary.
- The review delves into advancements in bioanalytical techniques and suggests strategies for better predicting drug interactions during the drug discovery process.
Article Abstract
Failure to evaluate actual toxicities of investigational molecules in drug discovery is majorly due to inadequate evaluation of their pharmacokinetics. Limitation of conventional drug metabolism profiling procedure demands advancement of existing approaches. Various techniques such as 3D cell culture system, bio microfluidic OoC model, sandwich culture model is in pipeline to be employed at their full potential in drug discovery phase. Although they outweigh the conventional techniques in various aspects, a more detailed exploration of applicability in terms of automation and high throughput analysis is required. This review extensively discusses various ongoing innovations in bioanalytical techniques. The review also proposed various scientific strategies to be adopted for prior assessment of interaction possibilities in translational drug discovery research.
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| http://dx.doi.org/10.4155/bio-2021-0001 | DOI Listing |
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