AI Article Synopsis
- A 14-year-old boy experienced severe seizures following a respiratory infection, leading to a diagnosis of Febrile Infection-Related Epilepsy Syndrome (FIRES).
- Initial tests including MRI and CSF analysis were normal, but he required multiple anticonvulsants due to ongoing, difficult-to-manage seizures.
- Despite various treatments for identified complications and an unsuccessful attempt to address Hemophagocytic lymphocytic histiocytosis (HLH), the overall outcome remained poor.
Article Abstract
A 14-year-old boy presented with a prodromal respiratory infection followed by super refractory status epilepticus. A diagnosis of Febrile Infection-Related Epilepsy Syndrome (FIRES) was made. Initial MRI study and CSF analysis were normal. He required multiple anticonvulsants owing to the refractory nature of the seizures. The course of the illness was rather stormy, laced with various medical problems viz. hepatic dysfunction, sepsis, hemodynamic, and hematological abnormalities which posed several challenges in the management. Hemophagocytic lymphocytic histiocytosis (HLH) was identified as the etiology of the illness and was treated but without success. The case report highlights the several immunomodulatory strategies that were employed to treat the disease, despite which the outcome was unfavorable.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918320 | PMC |
| http://dx.doi.org/10.1002/epi4.12454 | DOI Listing |
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