The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925875 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.628705 | DOI Listing |
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