In an effort to determine the effects of 5 (CHO-5), 6 (CHO-6), and 7.5 (CHO-7.5) percent carbohydrate solutions on gastric emptying and performance, 8 trained male cyclists performed 4 trials of intermittent (7- x ;12-min bout) cycling at 70% VO2max. A final 12-min self-paced "performance" ride was performed on an isokinetic ergometer (Fitron) interfaced with a computer to provide total work output. A water placebo (WP) was used as a control. Each 12-min ride was followed by 3-min rest, during which a drink was consumed (8.5 ml.kg-1; mean total = 1,336 ml.2 h-1). Blood samples were taken at 0, 25, 55, 85, and 115 min for blood glucose analysis. Following the performance ride, gastric residue was obtained by intubation and aspiration. Of the original 1,336 ml ingested during each trial, the volumes emptied by the stomach for the four trials were 1,306 +/- 76, 1,262 +/- 82, 1,288 +/- 75, and 1,278 +/- 77 ml (+/- SE) for WP, CHO-5, CHO-6, and CHO-7.5, respectively. Only the volume in the CHO-5 trial was significantly different from WP. The performance data showed that in all of the CHO trials, significantly more work was produced compared to the WP trial (CHO-5 = 1.98 +/- 0.09 x 10(5) Nm vs WP = 1.83 +/- 0.11 x 10(5) Nm). There were no significant differences in performance between any of the CHO trials.(ABSTRACT TRUNCATED AT 250 WORDS)
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http://dx.doi.org/10.1249/00005768-198820020-00002 | DOI Listing |
Diabetes
January 2025
Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia.
Individuals with type 2 diabetes are at high risk of postprandial falls in blood pressure (BP) (i.e., a reduction in systolic BP of ≥20mmHg, termed postprandial hypotension (PPH)), which increases the risk of falls and mortality.
View Article and Find Full Text PDFAm J Gastroenterol
January 2025
Department of Anatomy and Cell Biology.
Background: This study aimed to quantitatively examine gastric mucosal nerve density (GMND) in patients with functional dyspepsia (FD) and analyzed its clinical correlation.
Methods: We prospectively enrolled 35 patients with FD and 16 age-and gender-matched healthy controls for comparison of GMND on endoscopic biopsy, scores of Gastroparesis Cardinal Symptom Index (GCSI), and gastric emptying scintigraphy (GES).
Results: Patients with FD had lower GMND than the control subjects in gastric antrum, body, and fundus.
J Nutr Sci Vitaminol (Tokyo)
January 2024
Department of Nutrition Science, Faculty of Nursing and Nutrition, University of Nagasaki.
Carbohydrate-rich solid foods, such as bread, pasta, and steamed rice, are applied for test meals in studies examining digestion and absorption of food related to glucose metabolism and sports science. Such research must consider that drinking water is sometimes better as it avoids the risk of choking or aspiration. However, the water increases test meal volume and dilutes glucose concentration, which may influence the digestion and absorption of ingested foods, as well as energy metabolism.
View Article and Find Full Text PDFChin Med
January 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Background: Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has demonstrated significant efficacy in treating paediatric indigestion. It originates from Jianpi Pill, which is developed in the Ming Dynasty and nourishes the spleen and regulates gastrointestinal function. However, the specific molecular mechanisms involved remain unclear.
View Article and Find Full Text PDFBMC Surg
January 2025
Department of General, Visceral and Transplantation Surgery, LMU University Hospital Munich, LMU Munich, Munich, Germany.
Background: Pancreatic ductal adenocarcinoma (PDAC) typically occurs in an older patient population. Yet, early-onset pancreatic cancer (EOPC) has one of the fastest growing incidence rates. This study investigated the influence of age and tumor location on postoperative morbidity and mortality in a large, real-world dataset.
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