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Metastatic Hobnail Papillary Thyroid Carcinoma Initially Diagnosed by Pleural Effusion: Case Report of a Rare and Intriguing Entity.
Diagn Cytopathol
January 2025
Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA.
Hobnail papillary thyroid carcinoma (HNPTC) is an unusual and aggressive variant of PTC. Malignant pleural effusion secondary to thyroid carcinoma is a rare event reported in less than 1% of cases. Herein we present a case of metastatic HNPTC initially diagnosed by pleural effusion cytology, with a very poor outcome.
View Article and Find Full Text PDFRelapse of secondary syphilis in a PLHIV - A new entity.
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Department of Dermatology, Venereology and Leprosy, Sree Mookambika Medical College, Kanniyakumari, Tamil Nadu, India.
Syphilis and other bacterial sexually transmitted infections (STIs) are on the verge of resurge throughout the world. Coinfection of syphilis and HIV is quite common as they both share a common mode of transmission. The behavior of syphilis is quite altered in the presence of HIV.
View Article and Find Full Text PDFUnusual manifestations of syphilis in HIV.
Indian J Sex Transm Dis AIDS
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Department of Dermatology, Venereology and Leprosy, Osmania Medical College, Hyderabad, Telangana, India.
Over the past decade, there has been a significant increase in cases with syphilis and HIV coinfection. Concordant infection with HIV can alter the clinical course and response to treatment in syphilis. Variable and unusual presentations of syphilis in HIV disease can make early diagnosis and treatment challenging.
View Article and Find Full Text PDFXanthomatous hypophysitis relapsing and remitting over two decades.
Pract Neurol
January 2025
Neurology, University of Birmingham Institute of Immunology and Immunotherapy, Birmingham, UK.
Inflammation of the pituitary gland can be primary (without another underlying cause) or secondary (associated with a systemic inflammatory condition). Primary hypophysitis is very rare, among which xanthomatous hypophysitis as a histological type is extremely unusual. A woman in her late 50s presented with recurrent pituitary lesions over 20 years.
View Article and Find Full Text PDFDetermination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau.
ACS Chem Neurosci
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Department of Chemistry, University of California, Riverside, California 92521, United States.
Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins.
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