Hypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Recent studies have shown that some non-coding RNA implicated the formation of HS, but the mechanism remains unclear. In this study, we found that lncRNA TRHDE-AS1 was downregulated in HS tissues and HSFs, and the level of lncRNA TRHDE-AS1 negatively correlated with the level of miR-181a-5p in HS tissue and HSFs. Overexpressed lncRNA TRHDE-AS1 significantly suppressed miR-181a-5p level, while promoted HSFs apoptosis and inhibited HSFs proliferation. Further study shown that PTEN was a direct target of miR-181a-5p, and lncRNA TRHDE-AS1 served as a molecular sponge for miR-181a-5p to regulate the expression of PTEN. Overexpression of PTEN could eliminate lncRNA TRHDE-AS1-mediated proliferation suppression of HSFs. In conclusion, our study suggested that lncRNA TRHDE-AS1/miR-181a-5p/PTEN axis plays an important role in promoting hypertrophic scar formation, which may be effectively used as a therapeutic target for hypertrophic scar treatment.
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| http://dx.doi.org/10.1007/s10735-021-09968-y | DOI Listing |
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Article Synopsis
- Research highlights the increasing importance of long non-coding RNAs (lncRNAs) in cancer, specifically noting significant roles for various lncRNAs in glioma development.
- The study focuses on TRHDE-AS1, revealing its correlation with tumor prognosis and differences in expression across various glioma classification types, suggesting its relevance in glioma pathology.
- Findings indicate that TRHDE-AS1 may influence synapse-related functions and is linked to key cancer driver genes, as well as the glioma immune microenvironment, positioning it as a potential biomarker for glioma prognosis.
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