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| http://dx.doi.org/10.1007/s43678-021-00107-w | DOI Listing |
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Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.
PLoS Biol
January 2025
Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed. In this study, we utilized virtual screening to search for drug-like molecules that bind to the orthosteric site of rod opsin and improve its folding and trafficking.
View Article and Find Full Text PDFBlockchain-enabled digital twin system for brain stroke prediction.
Brain Inform
January 2025
Department of Computing, Glasgow Caledonian University, Glasgow, G4 0BA, Scotland.
A digital twin is a virtual model of a real-world system that updates in real-time. In healthcare, digital twins are gaining popularity for monitoring activities like diet, physical activity, and sleep. However, their application in predicting serious conditions such as heart attacks, brain strokes and cancers remains under investigation, with current research showing limited accuracy in such predictions.
View Article and Find Full Text PDFResonant Auger Decay in Benzene.
J Phys Chem A
January 2025
Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States.
We present ab initio calculations of the resonant Auger spectrum of benzene. In the resonant process, Auger decay ensues following the excitation of a core-level electron to a virtual orbital. Hence, resonant Auger decay gives rise to higher-energy Auger electrons compared to nonresonant decay.
View Article and Find Full Text PDFVirtual Monitoring Technician Performance in High-Fidelity Simulations of Remote Patient Monitoring: An Exploratory Study.
Simul Healthc
January 2025
From the Department of Human Factors (H.S., Y.P., E.T., L.D.W.), Center for the Simulation, Research, and Patient Safety, Carilion Clinic, Roanoke, VA; and Health Systems and Implementation Science (S.H.P.), Virginia Tech Carilion School of Medicine, Roanoke, VA.
Introduction: Virtual Monitor Technicians (VMTs) are crucial in remotely monitoring inpatient telemetry. However, little is known about VMT workload and intratask performance changes, and their potential impact on patient safety. This exploratory study used a high-fidelity simulation aimed to evaluate VMTs' workload and performance changes over time in telemetry monitoring and identify future research directions for performance improvement.
View Article and Find Full Text PDFAdapting lateral stepping control to walk on winding paths.
J Biomech
January 2025
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:
Most often, gait biomechanics is studied during straight-ahead walking. However, real-life walking imposes various lateral maneuvers people must navigate. Such maneuvers challenge people's lateral balance and can induce falls.
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