AI Article Synopsis
- The insulin/IGF-1 signaling mutant shows a metabolic shift towards storing fats and carbs, which may be related to increased lifespan and resistance to stress.
- In these mutants, trehalose, a sugar, is found in higher amounts and helps stabilize proteins while protecting them from extreme conditions like heat and cold.
- The study indicates that while trehalose accumulation contributes to better resistance to certain stresses, it does not significantly extend lifespan, suggesting that stress resistance and longevity can operate independently.
Article Abstract
The insulin/IGF-1 (insulin-like growth factor 1) signaling mutant recapitulates the dauer metabolic signature-a shift towards lipid and carbohydrate accumulation-which may be linked to its longevity and stress resistance phenotypes. Trehalose, a disaccharide of glucose, is highly upregulated in mutants and it has been linked to proteome stabilization and protection against heat, cold, desiccation, and hypoxia. Earlier studies suggested that elevated trehalose levels can explain up to 43% of the lifespan extension observed in mutants. Here we demonstrate that trehalose accumulation is responsible for increased osmotolerance, and to some degree thermotolerance, rather than longevity in mutants. This indicates that particular stress resistance phenotypes can be uncoupled from longevity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917784 | PMC |
| http://dx.doi.org/10.3390/metabo11020105 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effective adaptation of flight muscles to tebuconazole-induced oxidative stress in honey bees.
Heliyon
January 2025
Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, István Street 2, H-1078, Budapest, Hungary.
The widespread and excessive agricultural use of azole fungicide tebuconazole poses a major threat to pollinator species including honey bee colonies as highlighted by recent studies. This issue is of growing importance, due to the intensification of modern agriculture and the increasing amount of the applied chemicals, serving as a major and recent problem from both an ecotoxicological and an agricultural point of view. The present study aims to detect the effects of acute sublethal tebuconazole exposure focusing on the redox homeostasis of honey bee flight muscles.
View Article and Find Full Text PDFG462S substitution of AaCYP51 confers moderate resistance to tebuconazole in Alternaria alternata.
Pest Manag Sci
January 2025
Department of Crop Protection, Zhejiang Agriculture and Forest University, Hangzhou, China.
Background: Tobacco brown spot (TBS) caused by Alternaria alternata is one of the most common diseases of tobacco in China, resulting in large loss in yield and quality. Demethylation inhibitors (DMIs) such as tebuconazole are commonly used pesticides to control TBS. However, their control effect has shown a downward trend in recent years.
View Article and Find Full Text PDFImpact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections: A Retrospective Multicenter Study.
Clin Infect Dis
January 2025
Infectious Diseases Unit, Policlinico San Martino Hospital-IRCCS, Genoa, Italy.
Background: This study assesses the impact of fluconazole resistance on 30-day all-cause mortality and 1-year recurrence in patients with Candida parapsilosis bloodstream infections (BSI).
Methods: A multicenter retrospective study was performed at 3 hospitals in Italy and Spain between 2018 and 2022. Adult patients with positive blood cultures for C.
ZjMAPKK4 Interacted With ZjNAC78 Regulates Cold Tolerance Response in Jujube.
Plant Cell Environ
January 2025
College of Horticulture, Hebei Agricultural University, Baoding, Hebei, China.
Jujube (Ziziphus ujuba Mill.) holds great importance as a fruit tree in China, with strong tolerance to drought and saline stress, but its growth is limited by vulnerability to cold stress. Consequently, the role of MAPK cascades in mediating jujube cold stress response remains unclear, with the specific function of ZjMAPKK4 in this context yet to be fully elucidated.
View Article and Find Full Text PDFForce Nanoscopy Demonstrates Stress-Activated Adhesion between Iron-Regulated Surface Determinant Protein B and Host Toll-like Receptor 4.
ACS Nano
January 2025
Louvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
The iron-regulated surface determinant protein B (IsdB) has recently been shown to bind to toll-like receptor 4 (TLR4), thereby inducing a strong inflammatory response in innate immune cells. Currently, two unsolved questions are (i) What is the molecular mechanism of the IsdB-TLR4 interaction? and (ii) Does it also play a role in nonimmune systems? Here, we use single-molecule experiments to demonstrate that IsdB binds TLR4 with both weak and extremely strong forces and that the mechanostability of the molecular complex is dramatically increased by physical stress, sustaining forces up to 2000 pN, at a loading rate of 10 pN/s. We also show that TLR4 binding by IsdB mediates time-dependent bacterial adhesion to endothelial cells, pointing to the role of this bond in cell invasion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!