8-Hydroxybriaranes from Octocoral (Briareidae) (Kükenthal, 1908).

Chemical investigation of the octocoral , collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (), as well as the previously reported metabolites, solenolide C () and briarenolide S (). The structures of briaranes - were characterized through spectroscopic analysis, and the absolute configuration of was corroborated by a single-crystal X-ray diffraction analysis. Briarane exhibited bioactivity against the protein expression of inducible nitric oxide synthase (iNOS).