A reduction in daily caloric or nutrient intake has been observed to promote health benefits in mammals and other vertebrates. Feed Restriction (FR), whereby the overall food intake of the organism is reduced, has been explored as a method to improve metabolic and immune health, as well as to optimize productivity in farming. However, less is known regarding the molecular and physiological consequences of FR. Using the model organism, , we investigated the impact of a short-term (month-long) FR on growth, gut morphology and gene expression. Our data suggest that FR has minimal effects on the average growth rates, but it may affect weight and size heterogeneity in a sex-dependent manner. In the gut, we observed a significant reduction in gut circumference and generally lower mucosal heights, whereas other parameters remained unchanged. Gene Ontology (GO), EuKaryotic Orthologous Groups (KOG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified numerous metabolic, reproductive, and immune response pathways that were affected by FR. These results broaden our understanding of FR and contribute towards growing knowledge of its effects on vertebrate health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917766 | PMC |
| http://dx.doi.org/10.3390/ijms22041814 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feed efficiency and resilience in dairy ewes subjected to a nutritional challenge.
J Dairy Sci
January 2025
Instituto de Ganadería de Montaña (CSIC-University of León), Finca Marzanas s/n, 24346 Grulleros, León, Spain.
It is currently uncertain how selection of more efficient animals might impact other traits such as resilience (which, in this context, is defined as the ability of an animal to sustain or revert quickly to its previous production level and health status after a disturbance), especially in small ruminants. However, improving, or at least maintaining, resilience is of utmost importance to ensure livestock production in the face of external perturbances, which are expected to become more prevalent in the near future due to climate change and global instability. This study was conducted to investigate whether a nutritional challenge consisting of animals receiving only 70% of their voluntary feed intake (DMI) for 26 d, might differentially affect the response of high- and low-feed efficiency (FE) sheep.
View Article and Find Full Text PDFThe Ability to Digest Cellulose Can Significantly Improve the Growth and Development of Silkworms.
Insects
December 2024
Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China.
Cellulose is essential in the growth and development of herbivores. However, its limited utilization by herbivores is a key factor restricting their feed conversion rates. Cellulase can hydrolyze cellulose into glucose, and the addition of exogenous cellulase preparations to feed is an effective method for improving the cellulose utilization rate of ruminants.
View Article and Find Full Text PDFFactors influencing direct breastfeeding of preterm infants in neonatal wards and the provision of breastfeeding support: a qualitative systematic review protocol.
JBI Evid Synth
January 2025
Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada.
Objective: The objective of this review will be to synthesize the qualitative evidence on factors that influence direct breastfeeding of preterm infants in neonatal wards and the provision of breastfeeding support.
Introduction: Breastmilk is critical for the health of preterm neonates, and infants who directly feed at the breast are more likely to receive breastmilk exclusively for longer periods. Direct breastfeeding is associated with improved maternal coping and development of maternal identity.
Assessing the impact of intermittent fasting and a low-carbohydrate-high-protein diet on metabolic health and pancreatic histopathology in type 2 diabetic rat model.
Int J Health Sci (Qassim)
January 2025
Department of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, 51452 Buraidah, Saudi Arabia.
Objective: The current study was conducted to investigate the effect of intermittent fasting (IF) with a low-carbohydrate-high-protein (LCHP) diet on blood glucose control in streptozotocin (STZ)-nicotinamide-induced type 2 diabetic rats (DR).
Methods: Thirty male Wistar rats were divided into six groups ( = 5) including a group of normal rats (NR) that received a control diet (CD) (50% carbohydrates, 17% protein, and 33% fat) with (AL) feeding. The remaining 5 groups were DR injected with STZ and fed on CD or LCHP diet (40% carbohydrates, 30% protein, and 30% fat) for 6 weeks, either AL or IF (with a time-restricted feeding of 16 h followed by 8 h feeding period).
The impact of dietary metabolizable energy levels on the performance of medium-sized geese: A systematic review.
Poult Sci
December 2024
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China; Key Laboratory of Exploration and Innovative Utilization of White Goose Germplasm Resources in the Cold Region of Heilongjiang Province, Daqing 163319, China.
This study aimed to investigate the effects of dietary metabolizable energy levels on various performance indicators of medium-sized geese, with the goal of predicting the optimal range of these energy levels. A comprehensive literature search was conducted across several databases, including Chinese National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, PubMed, Web of Science, and ScienceDirect, covering the period from January 1, 2000, to July 1, 2024. The gathered studies focused on the impact of dietary metabolizable energy levels on the production performance of medium-sized geese.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!