Application of LC-MS/MS-based molecular networking indicated the ethanol extract of octocoral is a potential source for the discovery of new xenicane derivatives. A natural product investigation of this soft coral resulted in the isolation of four new xenicane diterpenoids, asterolaurins O‒R (‒), together with six known compounds, xeniolide-A (), isoxeniolide-A (), xeniolide-B (), 7,8-epoxyxeniolide-B (), 7,8-oxido-isoxeniolide-A (), and 9-hydroxyxeniolide-F (). The structures of isolated compounds were characterized by employing spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Asterolaurin O is the first case of brominated tricarbocyclic type floridicin in the family Xeniidae. Concerning bioactivity, the cytotoxic activity of those isolates was evaluated. As a result, compounds and demonstrated a selective cytotoxic effect against the MCF-7 cell line at IC of 14.7 and 25.1 μM, respectively.
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| http://dx.doi.org/10.3390/md19030123 | DOI Listing |
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