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First Investigative Study of Azole-Resistant in the Environment in Burkina Faso. | LitMetric

AI Article Synopsis

  • - A study was conducted in Burkina Faso to investigate the prevalence of azole-resistant (ARAF) strains due to limited data on these strains in Africa, highlighting environmental factors that suggest their presence.
  • - Researchers collected and analyzed 120 soil samples, utilizing azole-containing agar plates for resistance screening and the EUCAST method to confirm resistance.
  • - Among the samples, one ARAF isolate (2%) was identified, carrying specific mutations, marking the first report of azole resistance in Burkina Faso.

Article Abstract

Azole-resistant (ARAF) strains have been reported on all continents, however, limited data exist on these strains in Africa, while several factors, mainly environmental ones, suggest their presence on this continent. This study aimed to assess the environmental prevalence of ARAF strains in Burkina Faso, a country situated in the West African region where data on ARAF is non-existent. In total, 120 environmental samples (soil) were collected and analyzed. Samples were screened for resistance using three azole-containing agar plates; one without azole antifungal (growth control) and two supplemented with either itraconazole (4 mg/L) or voriconazole (2 mg/L). The EUCAST susceptibility testing method was used to confirm the azole-resistant phenotype of sensu-stricto isolates. Mutations in the gene were determined by sequencing. Of the 120 samples, 51 positive samples showed growth of isolates on control medium. One ARAF (2%; 1/51) isolate was found amongst positive samples and harbored the F46Y/M172V/E427K mutations. No TR34/L98H or TR46/Y121F/T289A mutations were observed. Our study described the first isolate resistant to an azole antifungal in Burkina Faso.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956412PMC
http://dx.doi.org/10.3390/ijerph18052250DOI Listing

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