AI Article Synopsis
- NNMT is an enzyme that transfers methyl groups from SAM to nicotinamide and is found in various tissues like the liver, fat, and muscles.* -
- Recent research has connected NNMT expression to cancer cell lines and metabolic diseases.* -
- The study focuses on finding effective small molecule inhibitors for NNMT using X-ray crystallography to explore different binding modes.*
Article Abstract
Nicotinamide--methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from -adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expression in several cancer cell lines has been widely discussed in the literature, and recent work established a link between NNMT expression and metabolic diseases. Here we describe our approach to identify potent small molecule inhibitors of NNMT featuring different binding modes as elucidated by X-ray crystallographic studies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918612 | PMC |
| http://dx.doi.org/10.3390/molecules26040991 | DOI Listing |
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