AI Article Synopsis
- Endometrial cancer (EC) treatment varies by stage and risk factors, with surgery being the common method for early-stage patients, while higher grade cases may need additional therapy.
- This study aimed to analyze miRNA gene expression to find differences between EC grades, using tumor samples from 24 patients and validating findings with data from 407 tumors in the Cancer Genome Atlas (TCGA).
- Key results showed significant differences in miRNA expression levels between low and high grades, identifying miR-375 and miR-190b as potential biomarkers for differentiating high-grade EC, highlighting the variability in grade 2 samples and suggesting viral influence on cancer progression.
Article Abstract
Endometrial cancer (EC) is treated according to the stage and prognostic risk factors. Most EC patients are in the early stages and they are treated surgically. However some of them, including those with high grade (grade 3) are in the intermediate and high intermediate prognostic risk groups and may require adjuvant therapy. The goal of the study was to find differences between grades based on an miRNA gene expression profile. Tumor samples from 24 patients with grade 1 ( = 10), 2 ( = 7), and 3 ( = 7) EC were subjected to miRNA profiling using next generation sequencing. The results obtained were validated using the miRNA profile of 407 EC tumors from the external Cancer Genome Atlas (TCGA) cohort. We obtained sets of differentially expressed (DE) miRNAs with the largest amount between G2 to G1 (50 transcripts) and G3 to G1 (40 transcripts) patients. Validation of our results with external data (TCGA) gave us a reasonable gene overlap of which we selected two miRNAs (miR-375 and miR190b) that distinguish the high grade best from the low grade EC. Unsupervised clustering showed a high degree of heterogeneity within grade 2 samples. MiR-375 as well as 190b might be useful to create grading verification test for high grade EC. One of the possible mechanisms that is responsible for the high grade is modulation by virus of host morphology or physiology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918779 | PMC |
| http://dx.doi.org/10.3390/biom11020274 | DOI Listing |
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