Tools for Assessing Translation in .

J Fungi (Basel)

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14201, USA.

Published: February 2021

is a ubiquitous environmental fungus capable of establishing an infection in a human host. Rapid changes in environments and exposure to the host immune system results in a significant amount of cellular stress, which is effectively combated at the level of translatome reprogramming. Repression of translation following stress allows for the specific reallocation of limited resources. Understanding the mechanisms involved in regulating translation in during host infection is critical in the development of new antifungal drugs. In this review, we discuss the main tools available for assessing changes in translation state and translational output during cellular stress.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995980PMC
http://dx.doi.org/10.3390/jof7030159DOI Listing

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