AI Article Synopsis
- Platelets are crucial for stopping bleeding (haemostasis) and their dysfunction can lead to hemorrhagic or clotting disorders (thrombocytopathies).
- The review discusses traditional issues with platelets, including how they stick to each other and release chemicals in the blood.
- It emphasizes the importance of studying procoagulant platelets—those that help blood clotting—when investigating potential platelet-related diseases.
Article Abstract
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956450 | PMC |
| http://dx.doi.org/10.3390/jcm10050894 | DOI Listing |
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