AI Article Synopsis
- Advanced Alzheimer's disease (AD) shows increased levels of noradrenaline metabolites, indicating a potential link between these levels and AD pathology.
- The study examined 77 memory clinic patients, analyzing brain structure and fluid biomarkers to assess the relationship between noradrenaline turnover and brain morphology, focusing on the role of the locus coeruleus (LC).
- Results revealed that higher levels of the noradrenergic metabolite MHPG correlate with reduced cortical thickness and hippocampal volume, suggesting that these changes may occur early in the AD process, possibly aiding in early detection of the disease.
Article Abstract
Advanced Alzheimer's disease (AD) is characterized by higher noradrenaline metabolite levels that may be associated with AD pathology. The locus coeruleus (LC) is the main site for cerebral noradrenaline synthesis and LC volume loss occurs as early as Braak stage 1. This study investigates the association between noradrenergic turnover and brain morphology, and the modifying effect of AD pathology. The study sample included 77 memory clinic patients (37 cognitively unimpaired and 40 cognitively impaired (mild cognitive impairment or AD dementia)). Cortical thickness and volumetric analyses were performed using FreeSurfer. Cerebrospinal fluid was analyzed for noradrenergic metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), Aβ42 and phosphorylated tau. Higher MHPG was associated with lower cortical thickness and hippocampal volume at lower, but subthreshold, levels of Aβ42 and at higher p-tau levels. These associations remained significant after adding APOE-E4 or cognitive status as covariates. Our results suggest that greater MHPG together with worse AD pathology contributes to neurodegeneration, possibly before significant amyloidosis. The noradrenergic system may play an important role in early detection of AD-related processes.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2021.01.024 | DOI Listing |
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